Center for sensing technologies

Center for Innovation and Business Development

Project aim: The main goal of NANOFACTS is to enhance research capabilities at BioSense institute regarding research in cancer theranostics nanomaterials and biosensing diagnostics of cancer, and to promote collaboration with internationally leading institutions at EU level.
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About the project: In order to widen the research agenda at BIOS with cancer-related research and health-related biosensing technologies, NANOFACTS will harness and improve pre-existing links with two leading European research institutions in the field of nanotechnology and development of biosensors:
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•Trinity College Dublin (TCD), Ireland, The School of Pharmacy and Pharmaceutical Sciences, an expert in application of nanotechnology for cancer treatment and imaging; and its validation, including biocompatibility of nanoparticles/nanodevices.
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• Vienna University of Technology (TUW), Faculty of Technical Chemistry, Institute of Applied Synthetic Chemistry and Institute of Chemical Technologies and Analytics, an expert in devising health-related biosensors.
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The main strategies to be explored during the project activities will include:
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a) BIOS researchers gaining knowledge on devising theranostic nanoparticles for real-time in vivo detection of cancer biomarkers, along with simultaneous targeted cancer therapy and imaging and
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b) enhancing the capacity of biosensing technologies at BIOS with cancer-related biosensing, including construction of an array of user-friendly personalized point of-care microfluidic and electronic diagnostic devices for electronic and optical sensing of cancer biomarkers, which could be introduced to home disease-monitoring.
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<img decoding="async" loading="lazy" class="alignnone wp-image-713 " src="https://api.biosens.rs/wp-content/uploads/2021/06/NANOFACTS-ilustracija-300x206.jpeg" alt="" width="684" height="470" srcset="https://api.biosens.rs/wp-content/uploads/2021/06/NANOFACTS-ilustracija-300x206.jpeg 300w, https://api.biosens.rs/wp-content/uploads/2021/06/NANOFACTS-ilustracija-1024x704.jpeg 1024w, https://api.biosens.rs/wp-content/uploads/2021/06/NANOFACTS-ilustracija-768x528.jpeg 768w, https://api.biosens.rs/wp-content/uploads/2021/06/NANOFACTS-ilustracija.jpeg 1350w" sizes="(max-width: 684px) 100vw, 684px" />

Full research professor in the field of natural and mathematical sciences -chemistry

Nikola Knežević

Zoran Pavlović was born in 1986. in Aleksinac, Serbia. He obtained a Diploma in 2010., and an M.Sc. degree in 2011. in Chemical Engineering at the Faculty of Technology and Metallurgy, University of Belgrade. Master thesis about electrochemical catalysts and cyclone flow reactor fuel cell system development was done at the Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany. He obtained a Ph.D. degree in 2017. in Heterogeneous Electrochemical catalysis (Dr. Rer. Nat - Doctor of Natural Sciences), from the Max Planck Institute for Chemical Energy Conversion, Muelheim an der Ruhr, Germany, as well as from Fritz Haber Institute. Berlin, Germany. During his Ph.D. studies, he presented his work in various electrochemical conferences in Germany and at the Electrochemical society conferences in the USA (Orlando - Florida, and San Diego - California). Since March 2018. he has been working in Pharmaceutical company Phytonet AG, Zurich, Switzerland, where he is involved in starting up a production site of Pharmaceutical food supplement products in Novi Sad, Serbia. He works there as a Production Manager and Manager of Technical systems while doing Process development, Pharmaceutical Technology Transfer, Quality control, and Business development. At the same time since March 2018. he has been working as an Assistant Professor at the Faculty of Pharmacy, the University of Business Academy in Novi Sad, where he gives lectures on Industrial Pharmacy, Organic, Bioorganic, Stereo, and Steroid Chemistry, and supervise B.Sc., M.Sc., and Ph.D. students during their thesis development, and during their practical training in Phytonet AG. Since January 2021, Zoran has been working at the BioSense Institute as a Senior Researcher, joining on many ongoing European projects. His main research interest is the electrochemical catalysis in renewable energy storage, development of bio-electrochemical sensors and materials for applications in agriculture, medicine, pharmacy, and environmental protection.

Zoran Pavlović

Dr Radonic received a PhD in electronics in 2010 at University of Novi Sad. He authored and co-authored 2 book chapters, 30 journal papers, more than 60 conference papers, 10 technical solutions, and has more than 440 citations. Dr Radonić was the project leader in four Serbian national projects, one project financed by European Bank for Research and Development, one Bilateral project between Serbia and Slovenia, project financed by Good Food Institute, USA and WP leader in one FP7 project–InnoSense and one H2020 project–ANTARES. He participates in a number of research FP6, FP7, H2020, COST, EUREKA, IPA projects. He is a member of IEEE and MAGEO (Microwaves in Agriculture, Environment and Earth Observation) groups and was a member of Technical Program Committees of EUROCON (Computer as Tool, 2015) conference, Salamanca, Spain and Sensordevices conference 2019, Nice, France. Steering committee member of the BioSense Institute 2015-2020, and the vice president of Scientific council of the BioSense Institute 2015-2020. From 2022, he is the assistant director for science. Reviewer in different scientific journals: Scientific Reports, Lab-on-Chip, IEEE Sensors Journal, MDPI Sensors, MDPI Electronics, Sensors and Actuators B, IEEE Wireless and component letters, Electronic letters, etc. The main expertise of Dr Radonic is microfluidics, sensors development (microwave, optical, microfluidic sensors and biosensors), electronic, RF and microwave passive components (filters, coupler, diplexer, etc.), antennas and RFID systems, periodical and artificial materials, fabrication technologies, measurements and characterization.

Vasa Radonić

Stefan Jarić is employed at the Center for Sensing Technologies as a Research Assistant and a final-year PhD student in materials physics at the Department of Physics, Faculty of Sciences at the University of Novi Sad. Stefan works on the development and research of new solutions in the field of biosensors based on graphene field effect transistors and specific synthetic receptors (aptamers) for the detection of various analytes in the area of environmental protection (toxins) and medicine (biomarkers). His expertise is developing in the direction of micro and nanofabrication of sensor platforms (photolithography, physical vapor deposition of materials), characterization of materials (Raman spectroscopy, atomic force microscopy) and electrical characteristics of biosensors.

Stefan Jarić

Slavica Savić obtained her BSc degree in 2002. from the Faculty of Physical Chemistry, University of Belgrade. In 2009 she received her PhD degree in Materials in electronics, Faculty of Technical Sciences, University of Novi Sad. From Jan 2003-Sept. 2008 she worked at Institute of Technical Sciences of the Serbian Academy of Science and Arts as research assistant. From Sept. 2008.-July 2015 she worked as research assistant (2008-2010), research associate (2010- March 2015) and senior research associate (April 2015-July 2015) at Department of Material Science at Institute for Multidisciplinary Research, University of Belgrade. From July 2012 to December 2012 she was a visiting research scientist at Pontificia Universidade Catolica (PUC) Rio de Janeiro, Brasil. From July 2015-July 2020 she was senior research associate at BioSense Institute. Since July 2020 she is principal research fellow at BioSense Institute.Her research interest include advanced ceramic materials processing and characterization, materials science solid-state chemistry and physics. Specific field of research activity: Synthesis and characterisation of Eu, Zr, Nb and Ta - doped BCY10 cermets as electrolytes for IT-SOFC; Synthesis and characterization of thermistor material NiMn2O4 obtained mechanochemically and by complex polimerization method. Thermoelectric materials: Mechanochemically assisted solid state synthesis of pure NaCo2O4 and doped with Cu; Synthesis of NaCo2O4 by citrate gel process. Current activities are focused to the synthesis and characterization of MOx (M=Ti, Sn, Zn) for applications in gas sensors and humidity sensors. The significance of her research is confirmed with more than 50 scientific papers in relevant scientific journals.

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Slavica Savić

Dr Nikolina Janković (F) senior researcher in the Center for Sensing Technologies in the BioSense Institute. Author and co-author of more than 40 journal and conference papers and 5 book chapters. Main research interest metamaterials, plasmonics, acoustics, sensors, and microwave passive devices. The coordinator of the H2020 MSCA-RISE project NOCTURNO and EUREKA project WaQUMoS in Serbia. Well versed in EU regulations and procedures and the EC funded projects. In the last seven years, participated in two FP7 projects: MultiWaveS and InnoSense (Financial and Administrative Manager and WP leader), as well as in three H2020 projects (H2020 Teaming ANTARES, NOCTURNO, and SHealthy).

Nikolina Janković

Dr. Nikola Knežević is a Full research professor at the Center for Sensor Technologies at the Biosense Institute. He received his doctorate in 2009 at Iowa State University, USA, in synthesizing and functionalizing porous silica nanoparticles for stimuli-responsive and targeted drug delivery. He gained further research experience as a postdoctoral fellow at the University of Houston (research in the field of multistep organic synthesis), Universidad Complutense de Madrid (nanomaterials science), Institute Charles Gerhardt Montpellier (nanomaterials science), FP7 - ERA ERA Chairs postdoctoral fellow at the Vinča Nuclear Institute and as Pole Chimie Ballard Visiting Professor at the University of Montpellier. Nikola is the author/co-author of over 40 scientific publications, including 2 book chapters and one patent, with over 1900 citations and an H index of 21. Nikola is the coordinator of one H2020 project (NANOFACTS GA 952259), three Serbian national projects (PRECAST – 6060755, proof of concept – 5566, technology transfer -1135), and two bilateral research projects (with France and Germany). Research interests: Synthesis of functional bioresponsive nanomaterials for use in health protection and construction of biosensors.

Mirjana Mundžić has a Bachelor and Master`s degree in Biochemistry. She is currently a PhD Student of Biochemistry at the Faculty of Sciences in Novi Sad and a Junior Research Assistant at the BioSense Institute. Her main research interests are evaluation of cytotoxicity of nanomaterials along with the evaluation of their biocompatibility and bioactivity.

Mirjana Mundžić

Nejra Omerović is a Research Assistant at the BioSense Institute. She received her BSc and MSc degree in 2015 and 2017, respectively, from the Faculty of Technology, University of Novi Sad, Serbia, where she is currently a PhD student at the Department of Materials engineering. From October 2015 to September 2016 she did an internship at AGFA-Gevaert NV, Mortsel, Belgium, where she worked at the Inkjet Ink Development Department. Her current research activities are focused on biopolymers and their nanocomposites.

Nejra Omerović

Minja Mladenović is a Junior Research Assistant at the BioSense Institute and a Ph.D. student of Chemistry at the Faculty of Sciences, University of Novi Sad. She received her Bachelor (2015) and Master (2016) degrees from the Department of Chemistry, Biochemistry and Environmental Protection at the Faculty of Sciences, as well. Her research interests include synthesis, functionalization and characterization of silica-based nanomaterials and their application in stimuli-responsive and controlled drug/biomolecules delivery.

Minja Mladenović

Dr Marko Radović graduated in 2005 from the Faculty of Physics, University of Belgrade. In 2008 he received a MSc degree at the Faculty of Physics, University of Belgrade. He received PhD title in 2015 also at Faculty of Physics, University of Belgrade. From April 2006. to February of 2017. He was employed at the Institute of Physics in Belgrade. Since February 2017. He is employed as a senior researcher at BioSense Institute. Dr Radović research interests are focused on a bottom-up approach, involving synthesis, characterization and functionalization of nanomaterials to design of gas monitoring platforms, biosensors, optoelectronic and photocatalytic devices. He has published 25 scientific papers in international and domestic journals and he is a member of the Serbian Society for Ceramic Materials.

Marko Radović

Dr. Ivana Kundacina is a Research Associate at the BioSense Institute. She completed her bachelor’s and master’s degrees in physics and earned a Ph.D. in Applied Physics from the Faculty of Sciences, University of Novi Sad, Serbia. She defended her Ph.D. thesis titled “Development and Implementation of New Sensor and Biosensor Solutions Integrated into the Lab-on-Chip Concept” in 2024. Throughout her career, Dr. Kundacina has been involved in eight national and international research projects and has worked as a visiting researcher at the Technical University of Vienna, Austria, and the French National Institute for Agriculture, Food, and Environment (INRAe) in Paris, France. Her research interests include microfluidics, CFD simulations, and the development of sensing and biosensing solutions integrated into miniaturized systems.

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Ivana Kundačina

Aleksandra Pavlović is a Junior Research Assistant at the BioSense Institute and a Ph.D. student of Chemistry at the Faculty of Sciences, University of Novi Sad. She received her Bachelor (2019) and Master (2020) degrees from the Department of Chemistry, Biochemistry and Environmental Protection at the Faculty of Sciences, as well. Her research interests include synthesis, functionalization and characterization of periodically mesoporous organosilicate nanoparticles for dermal use, as well as the development of biosensors for various biomolecules.

Aleksandra Pavlović

Ms. Milica Trajkovic (F) is a certified PMI project manager professional (PMP), experienced in EU funded projects focused on Digital Agriculture and development of ICTs for AgriFood value chain. As a Head of Business Development Department, she is responsible for building new and maintaining fruitful partnership network of the Institute both with industry and academia in Serbia and across Europe. Milica manages multi-national and cross-sectoral consortia, supports Institute in new project preparations (from an idea to design and proposal establishment) and brings AgTech market trends closer to the BioSense scientists. One of her goals is to foster entrepreneurial mentality among Institutes’ employees and support them in their own entrepreneurship endeavors. In addition, she facilitates business acceleration for high-tech startups, SMEs and web entrepreneurs from the region with the main aim to bring start-up tech community closer to the AgriFood sector.

Milica Trajković

Maša Mimica works as a Project Manager at BioSense Institute, covering two equally important fields – H2020 financial management and project management of cascade funding projects. She has extensive experience in financial reporting at the project level, portfolio of 17M€ with a proven track-record in planning, reporting and analysis of business needs and other financial aspects of the Institute. Maša as part of Business Development Department collaborates with other cross-finance teams in driving strategic decisions and ongoing operations.
In parallel, Maša acts as a Project Manager for cascade funded sub-projects, previously in FP7 and now in H2020 programme. Thus, she has a vast experience in tailor-made innovation and acceleration activities, which led to market positioning and expansion of more than 150 SMEs, cross-cutting IT and agricultural sectors.
Maša has strong background in multinational environment, where working with different stakeholders across the board in various industries, contributed to the development of her business and interpersonal skills.

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Maša Mimica

Dr. Marko Panić is a research associate in the field of technical sciences and information technologies at the BioSense Institute. His doctoral dissertation is related to the development of algorithms for accelerated image reconstruction from incomplete measurements using a sparse representation of signals and statistical Markov random models. His research direction includes statistical modeling of multidimensional data obtained from different sensors. He is currently working on the analysis and processing of images obtained from hyperspectral and multispectral cameras using advanced machine learning methods with application in assessing the quality of fruits and vegetables. As a member of the BioSense team, he participated in Syngenta's "Crop Challenge" competition, which resulted in winning first place. He is actively involved in many projects from the Horizon 2020 call, including Antares, Cybele, Dragon and Flexirobots, as well as in projects with companies such as Krivaja, MK Agri and Delta Agrar.

Marko Panić

Teodora Knežić joined BioSense Institute as Junior Researcher in the Center for Biosystems. Teodora has a bachelor's and master's degrees in Molecular Biology and she is currently a Ph.D. student of Molecular Biology at the Faculty of Sciences, University of Novi Sad, Serbia, with Dr Ivana Gađanski as the mentor. During her studies she volunteered in the Laboratory for Biochemistry and Molecular Biology at the Faculty of Sciences where was involved in the analyses of gene expression of the European corn borer using techniques for RNA isolation, gel electrophoresis, cDNA synthesis, end-point and qPCR analysis. Also, at the Institute for Nuclear Sciences Vinča she was trained to work with human cancer cell cultures, perform viability assays and flow cytometry. Teodora has just completed a 3 month specialization practice in BioSense as well. Her main research interests are biosensor development and molecular techniques for pathogen detection, cellular agriculture and development of lab-on-a-chip platforms.

Teodora Knežić

Mila Djisalov has a BSc in Biochemistry and a Master’s degree in Molecular Biology. She is currently a Ph.D. Student of Biochemistry at the Faculty of Sciences in Novi Sad and a Junior Researcher in BioSense Institute. Her main research interests are biosensor development and molecular tools for pathogen detection, cellular agriculture, and the development of lab-on-a-chip platforms. Mila is also one of the co-founders of the student group The BioSense Alt. Protein Project formed at the BioSense Institute.

MIla Đisalov

Ivana Gadjanski PhD is Research Associate Professor at BioSense Institute, University of Novi Sad, Serbia. She graduated from the Faculty of Biology, University of Belgrade as the 1st in the class (2003). She obtained PhD in Neuroscience (summa cum laude -oral presentation) from Georg-August University &amp; Max Planck Institute for Biophysical Chemistry, Goettingen, Germany (2007) and worked as a postdoctorate researcher at Ludwig-Maximillian University, Munich, Germany. Ivana then turned to the bioengineering field and spent a year as a Fulbright Visiting Scholar at Columbia University, USA - Lab for Stem cells and Tissue Engineering (Head: prof. Gordana Vunjak-Novakovic). In BioSense, she is moving further into the cellular agriculture field - developing solutions for cultivated meat. She also works on biosensing for agrifood, biomedicine and environmental monitoring. Ivana is a grantee of the Good Food Institute and coordinator of Horizon2020 projects DRAGON GA 810755 and IPANEMA GA 872662.

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Ivana Gađanski

Nanofacts Logo

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 This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 952259.                          

Horizon 2020

Due to their small diameter (ca. 100 nm) and highly porous nature, mesoporous silica nanoparticles (MSNs) have high specific surface area (ca. 1000 m2/g) which can be utilized for a plethora of functionalizations, loading/adsorption of different molecules and their removal, or as a platform for signaling molecules to detect different analytes.

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Mesoporous organosilicate nanomaterial (also termed Periodic Mesoporous Organosilica (PMO)) contains a large percentage of organic groups within the nanosphere, exhibiting unique characteristics for different applications.

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Our research is being conducted toward design of new series of MSN and PMO nanomaterials, as well as their core/shell analogs.

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Surface of these nanomaterials is being modified with different molecules to specifically interact with desired tissues, pollutants, or analytes, for their efficient application in monitoring and protection of health, food and the environment.

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One of the research goals is to develop smart nanomaterials with stimuli-responsive release of MSN/PMO-loaded molecules for diagnostics, imaging, and therapy of cancer tissues.

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Polymer-MSN composite materials are also being developed for applications as antimicrobial smart food packaging and medical implants.

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Finally, PMO nanoparticles are being constructed for efficient UVA and UVB blocking and application in a safer generation of sunscreens.

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<img class="alignnone wp-image-1626 size-full" src="https://api.biosens.rs/wp-content/uploads/2021/06/slika-1.png" alt="" width="837" height="466" />

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<a href="https://api.biosens.rs/wp-content/uploads/2021/06/68.tif"><img class="alignnone size-medium wp-image-1526" src="https://api.biosens.rs/wp-content/uploads/2021/06/68.tif" alt="" width="1" height="1" /></a>

Projects:

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PRECAST: Prediction of Cancer Treatment Effectiveness with Stimuli-responsive Nanomaterials, Science Fund of the Republic of Serbia

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<a href="https://cordis.europa.eu/project/id/952259">NANOFACTS: Networking Activities for Nanotechnology-Facilitated Cancer Theranostics H2020-WIDESPREAD-2020-5 </a>

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Novel Active Components for Health- and Environment-friendly UV-Blocking Based on Enriched Organosilica Nanomaterials, Project ID: 5566, The Innovation Fund of the Republic of Serbia

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III 44006, Ministry of Education, Science, and Technological Development of the Republic of Serbia.

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Silica nanomaterials

Heart-on-chip based on induced pluripotent stem cell technology for patient treatment

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Portable mass spectrometer based on a quadrupole analyser for investigaiton of consumer food intake effects for personalised nutrition using.

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Skin protection from UV irradiation based on nanoparticles

Selective cancer therapy based on slow release of drugs from silica nanomaterials

Medical and healthcare applications

Biosensors are analytical devices for detection of the biologic material which may include biomolecules, biological structures or microorganisms (bacteria, viruses, algae, spores). Nowadays, they are being used for food safety evaluation, environmental monitoring, or for early detection of infectious diseases in biomedicine.

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We work on the development of new point-of-need biosensor transducers, biofunctionalization of the sensors with bioreceptors, and sensor integration into microfluidic systems. Developed biosensors are being implemented for detection of bacteria in food and water, detection of cyanobacterial toxins produced during harmful algal blooms, as well as for a fast detection of faecal bacteria and other microbiological pathogens in water.

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More concrete, we focus our research on development of new nanomaterials for functionalization of the biosensor electrodes and fabrication of new electrochemical transducers using different fabrication technologies. Particular attention is dedicated to new materials which will enable selective and efficient binding of the analytes and to the novel biosensor designs to increase the selectivity, sensitivity and limit of detection. Therefore, we develop the novel methods of graphene modification, and the mask-less methods of graphene patterning and integration to conventional industrial routes.

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A special focus is placed on biosensors containing enzymes, antibodies and nucleic acids (DNA, RNA) as recognition elements. This research is performed in close collaboration with the Center for Biosystems in which experts work on biomolecular engineering and molecular detection methods including the cutting-edge isothermal methods for nucleic acid amplification such as LAMP (loop-mediated isothermal amplification) and RPA (recombinase polymerase amplification) and other ways of molecular detection which can be well combined with the biosensing methods.

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In addition, BioSense Institute works on the new types of biosensors for monitoring nutrients and products of cellular metabolism during cultured meat production, as another example of excellent multidisciplinary collaboration with the Center for BioSystems and the researchers working on Cellular agriculture topics.

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<img class="alignnone wp-image-1508 " src="https://api.biosens.rs/wp-content/uploads/2021/06/58.png" alt="" width="701" height="417" />

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Collaborative projects with the Center for Biosystems:

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<a href="http://www.ipanema2020.com/">H2020 MSCA-RISE IPANEMA GA 872662</a> - Integration of PAper-based Nucleic acid testing mEthods into Microfluidic devices for improved biosensing Applications

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<a href="http://www.realsense.rs/">REALSENSE1</a> - Monitoring of cell culture parameters using sensors for biomass and nutrients/metabolites in media: Lab-on-a-Chip (LOC) approach, 2019-2021; Good Food Institute Inaugural Competitive Grant Program.

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<a href="http://www.realsense.rs/">REALSENSE2</a> – From lab-on-a-chip to custom bioreactor: scale up modeling study, 2020-2022 Good Food Institute Competitive Grant Program

Biosensors

Microfluidics deals with manipulation and control of small quantity of fluids in micro- and nano-channels and as such, it initiated revolution in different fields including microbiology, medicine, and chemical analysis.

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We focus our research on analysis and design of different microfluidic components, development of the new materials for microfluidic chips, and integration of the microfluidics with different detection systems and electronics. To that end, we employ different fabrication technologies PDMS, LTCC, 3D and inkjet printing, bio-printing, xurography, and hybrid technologies.

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Since the utilization of only one microfabrication technology cannot fulfill all the requirements set by the microfluidic chip, we also employ hybrid fabrication approach, i.e. we combine various technologies with various materials to realize microfluidic chips with high resolution, small dimension, and high flow rate. For instance, hybrid approach is used to develop multilayered filtration units, high flow rate mixers, as well as pollen separation pinch flow.

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Also, we integrate microfluidic concept and reagent storages with various transduction principles and sensors, to develop lab-on-a-chip platform which finds application in in-field environment monitoring, biomedicine and food analysis.

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Moreover, we work on development of microfluidic reactor that integrates cell culture system, different sensors for nutrient concentration and metabolic waste products measurement, optical detection system and electronics into single chip.

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Our efforts are also focused on medical applications - we combine the top notch microfluidic technologies and organ-on-a-chip concept, along with the technology of induced pluripotent stem cells, to design a new generation of heart-on-a-chip for the patient treatment.
In addition, we develop a microfluidic platform able to reproduce the dynamic and heterogeneity of the soil conditions while implementing monitoring systems for investigating the root/plant–microbiome interactions in a microfluidic device.

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<img class="alignnone wp-image-1529 size-full" src="https://api.biosens.rs/wp-content/uploads/2021/06/70.jpg" alt="" width="763" height="323" />

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PROJECTS:

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CISTEM - Heart On chip based on induced pluripotent Stem cell Technology for personalized Medicine, H2020-MSCA-RISE-2017, GA No. 778354

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REALSENSE1 - Monitoring of cell culture parameters using sensors for biomass and nutrients/metabolites in media: Lab-on-a-Chip (LOC) approach, 2019-2021; Good Food Institute Inaugural Competitive Grant Program.

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IPANEMA - Integration of PAper-based Nucleic acid testing mEthods into Microfluidic devices for improved biosensing Applications, H2020-MSCA-RISE-2019, 2020-2024. GA No. 872662,

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NANOFACTS - Networking Activities for Nanotechnology-Facilitated Cancer Theranostics, H2020 - WIDESPREAD-05-2020 – Twinning, 2021-2024. GA No. 952259

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Development and Integration of Microfluidic Biosensors for Meat Safety monitoring in farm-to-slaughterhouse continuum (DIBMES), Innovation fond, Serbia, Call: Proof of Concept ID: 5524

Microfluidics

Biomolecules, including DNA, RNA, proteins, peptides and the constellation of small molecules made by cells, are the molecules that fuel life. Biomolecular engineering (BME) is the analysis and engineering of these living systems. BME research uses techniques from synthetic biology, systems biology, biomedical research and biotechnology, biochemistry and biophysics of biological systems and cell biology to quantify and manipulate the structure and function of molecules and macromolecular assemblies for potential applications in:

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· Biotechnology: Biosensing and bioanalytical devices, microfluidics-enabled cell culture technologies, (e.g. organ-on-a-chip), development and application of novel molecular tools (applicable for food safety evaluation)

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· Fundamental processes of living systems: host pathogen interactions, cellular and subcellular organization, regulation and control of biological networks

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· Human and animal disease: design and engineering of diagnostic methodologies, cell and tissue engineering, delivery of therapeutics
In addition, BME research efforts include interdisciplinary activities, such as materials science and nano- and microelectronics, as well as computer science and applied mathematics.

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In that sense, BME is a very good example of the close multidisciplinary collaboration between the Center for Biosystems and the two other centers in BioSense Institute: Center for sensing technologies and Center for information technologies.

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Projects:

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H2020 MSCA-RISE IPANEMA GA 872662 - Integration of PAper-based Nucleic acid testing mEthods into Microfluidic devices for improved biosensing Applications

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<img class="alignnone wp-image-1421 size-full" src="https://api.biosens.rs/wp-content/uploads/2021/06/bs6.jpg" alt="" width="1100" height="624" />

Biomolecular engineering

NANOFACTS – Networking Activities for Nanotechnology-Facilitated Cancer Theranostics

Centar za senzorske tehnologije

Centar za inovacije i razvoj poslovanja

Cilj projekta: Glavni cilj NANOFACTS projekta je unapređenje istraživačkih sposobnosti na institutu Biosens u vezi sa razvojem nanomaterijala za primenu u terapiji, snimanju i dijagnostici raka, kao i unapređenje saradnje sa međunarodno vodećim EU institucijama.
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O projektu: U cilju proširenja agende istraživanja na institutu Biosens istraživanjima vezanim za lečenje, praćenje i dijagnostiku raka, NANOFACTS će iskoristiti i poboljšati postojeće veze sa vodećim evropskim istraživačkim institucijama u oblasti nanotehnologije i razvoja biosenzora:
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• Trinity College Dublin (TCD), Irska, Fakultet farmacije i farmaceutskih nauka, ekspert u primeni nanotehnologije za lečenje i snimanje raka; ispitivanje terapeutske efikasnosti i biokompatibilnosti nanočestica.
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• Tehnološki Univerzitet u Beču (TUW), Fakultet za tehničku hemiju, Institut za primenjenu sintetičku hemiju i Institut za hemijske tehnologije i analitiku, ekspert za konstrukciju biosenzora primenljivim u zdravstvu.
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Glavne strategije koje će se primenjivati tokom projektnih aktivnosti:
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a) Istraživači Instituta Biosens stiču znanje o konstrukciji teranostičkih nanočestica za otkrivanje biomarkera karcinoma in vivo, u realnom vremenu, zajedno sa istovremenom ciljanom terapijom i snimanjem karcinoma i
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b) jačanje kapaciteta biosenzorskih tehnologija na institutu biosens razvojem istraživanja iz oblasti biosenzora za detekciju raka, uključujući izgradnju niza mikrofluidnih i elektronskih dijagnostičkih uređaja za elektronsko i optičko otkrivanje biomarkera raka, koji bi se mogli primeniti i za kućno praćenje bolesti.
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Naučni savetnik u oblasti prirodno–matematičkih nauka -hemija

Mirjana Mundžić je završila osnovne i master studije iz biohemije. Trenutno je doktorand biohemije na Prirodno-matematičkom fakultetu u Novom Sadu i istraživač pripravnik na Institutu BioSens. Njeno glavno istraživačko interesovanje je procena citotoksičnosti nanomaterijala zajedno sa procenom njihove biokompatibilnosti i bioaktivnosti.

Zoran Pavlović rođen je 1986. godine u Aleksincu, Srbija. Diplomu je stekao 2010. godine, a Master diplomu 2011. godine iz hemijskog inženjerstva na Tehnološko-metalurškom fakultetu Univerziteta u Beogradu. Master teza o elektrohemijskim katalizatorima i razvoju sistema gorivih ćelija sa protočnim ciklonskim reaktorima urađena je na Max Planck Institutu za dinamiku složenih tehničkih sistema, Magdeburg, Nemačka. Doktorirao je 2017. godine na heterogenoj elektrohemijskoj katalizi (dr. Rer. Nat - doktor prirodnih nauka), na Max Planck Institutu za hemijsku konverziju energije, Muelheim an der Ruhr, Nemačka, kao i na Fritz Haber Institutu, Berlin, Nemačka. Tokom doktorskih studija, predstavljao je svoj naucni rad na raznim elektrohemijskim konferencijama u Nemačkoj, kao i na konferencijama Elektrohemijskog društva u SAD-u (Orlando - Florida i San Diego - Kalifornija). Od marta 2018. godine radi u farmaceutskoj kompaniji Phytonet AG, Zurich, Švajcarska, gde je uključen u pokretanje proizvodnog pogona farmaceutskih preparata dodataka ishrani u Novom Sadu. Tamo radi kao menadžer proizvodnje i menadžer tehničkih sistema, gde se bavi optimizacijom postojećih i razvojem novih farmaceutskih procesa proizvodnje i transfera tehnologija, kao i poslovnim razvojem,. U isto vreme, od marta 2018. godine radi kao docent na Farmaceutskom fakultetu Univerziteta u Novom Sadu, gde vodi predavanja iz Industrijske farmacije, Organske, Bioorganske, Stereo i Steroidne hemije, a takođe je i mentor studentima na master i doktorskim tezama, kao i na studentskim praksama u Phytonet-u. Od januara 2021. godine, Zoran radi na Institutu BioSense kao Stariji istraživač, pridružujući se brojnim tekućim evropskim projektima. Njegov glavni istraživački interes je elektrokemijska kataliza u cilju skladištenja energije dobijene obnovljivim izvorima energije, i razvoj bio-elektrohemijskih senzora i materijala za primenu u poljoprivredi, medicini, farmaciji i zaštiti životne sredine.

Dr Radonić je doktorirao iz oblasti elektronike 2010. godine na Univerzitetu u Novom Sadu. Autor je 2 poglavlja u knjizi, 30 radova u naučnim časopisima, više od 60 konferencijskih radova, 10 tehničkih rešenja i ima više od 440 citata. Dr Radonić je bio rukovodilac na četiri nacionalna projekta, jednom projektu koji je finansirala Evropska banka za istraživanje i razvoj, jednom bilateralnom projektu između Srbije i Slovenije, projektu koji je finansirao Good Food Institute iz SAD-a i vođa radnog paketa u jednom FP7 projektu – Innosens i jednom H2020 – Antares. Učestvovao je u brojnim istraživačkim projektima iz programa FP6, FP7, H2020, COST, Eureka, IPA. Član je grupa IEEE i MAGEO (Mikrotalasi u poljoprivredi, životnoj sredini i posmatranju Zemlje) i član tehničkih programskih odbora konferencije EUROCON (Computer as a Tool, 2015), Salamanka, Španija i Sensodevice konferencije 2019, Nica, Francuska. Član upravnog odbora Instituta BioSense od 2015-2020 i potpredsednik Naučnog veća Instituta BioSense 2015-2020. Od 2022 obavlja funkciju pomoćnika direktora za nauku. Recenzent u mnogim naučnim časopisima: Scientific Reports, Lab-on-Chip, IEEE Sensors Journal, MDPI Sensors, MDPI Electronics, Sensors and Actuators B, IEEE Wireless and component letters, Electronic letters, etc. Oblast naučnog istraživanja dr Radonića je mikrofluidika, razvoj senzora (mikrotalasni, optički, mikrofluidni senzori i biosenzori), elektronskih, RF i mikrotalasnih pasivnih komponenti (filteri, spojnica, diplekser itd.), antena i RFID sistema, periodični i veštački materijali, tehnologije fabrikacije, merenja i karakterizacija.

Stefan Jarić je zaposlen u Centru za senzorske tehnologije kao istraživač-saradnik i student završne godine doktorskih studija fizike materijala na Departmanu za fiziku, Prirodno-matematičkog fakulteta u Novom Sadu. Stefan se bavi razvojem i istraživanjem novih rešenja na polju biosenzora zasnovanih na grafenskim tranzistorima sa efektom polja i specifičnih sintetičkih receptora (aptamera) za detekciju raznih analita iz sfere zaštite životne sredine (toksini) i medicine (biomarkeri). Njegova ekpertiza se razvija u pravcu mikro i nanofabrikacije senzorskih platformi (fotolitografija, fizičko naparavanje materijala), karakterizacije materijala (Ramanova spektroskopija, mikroskopija atomskih sila) i električnih karakteristika biosenzora.

Slavica Savić je diplomirala 2002 godine na Fakultetu za fizičku hemiju, Univerzitet u Beogradu. Zvanje doktora nauka u oblasti materijala u elektronici je stekla 2009 godine na Fakultetu tehničkih nauka Univerziteta u Novom Sadu. Od januara 2003. do septembra 2008. radila je na Institutu tehničkih nauka SANU kao istraživač saradnik. Od septembra 2008. do jula 2015. bila je zaposlena kao istraživač saradnik, naučni saradnik i viši naučni saradnik na Odseku za materijale Instituta za multidisciplinarna istraživanja Univerziteta u Beogradu. Od jula 2012. do decembra 2012. bila je gostujući istraživač (istraživač na postdoktorskim studijama) na Pontificia Universidade Catolica (PUC), Rio de Janeiro, Brazil. Od jula 2015.do jula 2020. radila je kao viši naučni saradnik na Institutu BioSens. Od jula 2020. radi kao naučni savetnik u Centru za senzorske tehnologije Instituta BioSens. Učestvovala je na više nacionalnih i međunarodnih projekata a rukovodila je bilateralnim istraživačkim projektom sa Italijom kao i projektom finansiranim od Evropske banke za istraživanje i razvoj.Oblasti njenog istraživanja su nauka o materijalima, procesiranje keramičkih materijala i njihova karakterizacija, fizika i hemija čvrstog stanja. Specifična oblast istraživanja: Sinteza i karakterizacija dopirane BCY10 keramike primenjene kao elektrolita za srednjetemperaturne gorivne ćelije; sinteza i karakterizacija termistorskog materijala nikl manganita; Termoelektrični materijali: mehanohemijski podržana sinteza u čvrstom stanju kao i citratna gel sinteza čistog natrijum kobaltita kao i dopiranog bakrom. Trenutne istraživačke aktivnosti su usmerene ka sintezi i karakterizaciji metal oksidnih materijala MOx (M=Ti, Sn, Zn) sa primenom u gasnim senzorima i senzorima vlage kao i 2D materijalima kao gasnim senzorima za primenu u poljoprivredi, kao i medicinskim uređajima za analizu daha itd. Značaj njenih istraživanja je potvrđen sa više od 50 naučnih radova objavljenim u visoko rangiranim međunarodnim časopisima.

Dr Nikolina Janković je stariji Istraživač u Centru za senzorske tehnologije Instituta BioSens. Autor i koautor više od 40 radova u časopisima i na konferencijama, kao i 5 poglavlja u knjigama. Njena polja interesovanja uključuju metamaterijale, akustiku, plazmoniku, senzore i mikrotalasna pasivna kola. Koordinator je H2020 MSCA-RISE projekta NOCTURNO i EUREKA projekat WaQUMoS u Srbiji. In poslednjih sedam godina učestvovala je u 2 FP7 projekta MultiWaveS i InnoSense (menadžer projekta i vođa radnog paketa), kao i u 3 H2020 projekta (H2020 Teaming ANTARES (vođa radnog paketa), NOCTURNO (rukovodilac) i SHealthy).

Dr Nikola Knežević je Naučni savetnik u Centru za senzorske tehnologije na Institutu Biosens. Doktorirao je 2009. godine na Iowa State University, SAD, iz oblasti sinteze i funkcionalizacije poroznih silikatnih nanočestica za stimulans-responsivnu i ciljajuću isporuku lekova. Dalje istraživačko iskustvo stekao je kao postdoktorand na Univerzitetu u Hjustonu (istraživanje iz oblasti višestepene organske sinteze), Universidad Complutense de Madrid (nauka o nanomaterijalima), Institute Charles Gerhardt Montpellier (nauka o nanomaterijalima), FP7 – ERA ERA Chairs postdoktorand u Nuklearnom institutu Vinča i kao Pole Chimie Balard gostujući profesor na Univerzitetu u Monpeljeu. Nikola je autor/koautor na preko 40 naučnih publikacija, uključujući 2 poglavlja u knjigama i jedan patent, sa preko 1900 citata i H indeksom 21. Nikola je koordinator jednog projekta H2020 (NANOFACTS GA 952259), tri srpska nacionalna projekta (PRECAST – 6060755, dokaz koncepta – 5566, transfer tehnologija -1135) i dva bilateralna istraživačka projekta (sa Francuskom i Nemačkom). Istraživačka interesovanja: sinteza funkcionalnih bioresponsivnih nanomaterijala za primenu u zaštiti zdravlja i konstrukciji biosenzora.

Nejra Omerović je zaposlena na Institutu BioSens kao istraživač saradnik. Osnovne i master studije završila je 2015., odnosno 2017. godine na Tehnološkom fakultetu, Univerzitet u Novom Sadu, Srbija, gde je trenutno sudent doktorskih studija na Katedri za Inženjerstvo materijala. Od oktobra 2015. do septembra 2016. godine obavljala je stručnu praksu u kompaniji AGFA-Gevaert NV, Mortsel, Belgija, gde je radila na Departmanu za razvoj inkdžet mastila. Njene trenutne istraživačke aktivnosti usmerene su na biopolimere i njihove nanokompozite.

Minja Mladenović je zaposlena na Institutu BioSens kao istraživač-pripravnik. Takođe, student je doktorskih akademskih studija hemije na Prirodno-matematičkom fakultetu Univerziteta u Novom Sadu, gde je završila osnovne i master studije hemije. Bavi se naučno-istraživačkim radom u oblasti sinteze, funkcionalizacije i karakterizacije nanomaterijala na bazi silike, kao i primenom istih za stimulisanu i kontrolisanu isporuku lekova i biomolekula.

Dr Marko Radović je diplomirao 2005. na Fizičkom Fakultetu pri Beogradskom univerzitetu. 2008. je odbranio magistarski rad na Fizičkom Fakultetu na Univerzitetu u Beogradu. Doktorsku disertaciju je odbranio 2015. na Fizičkom Fakultetu u Beogradu. Od aprila 2006. je zaposlen na Institutu za Fiziku u Beogradu. Od februara 2015. je zaposlen kao naučni saradnik na Biosens Institutu. Naučno istraživačka delatnost Dr Radovića je fokusirana na tzv. “bottom-up approach” gde su povezane sinteza nanomaterijala, karakterizacija I funkcionalizacija nanomaterijala u dizajnu senzorskih optoelektronskih i fotokatalitičkih uređaja. Tokom dosadašnje karijere publikovao je više od 25 naučnih radova u međunarodnim i domaćim časopisima.

Dr Ivana Kundačina je naučni saradnik na Institutu Biosens. Završila je osnovne i master studije fizike, kao i doktorske studije primenjene fizike na Prirodno-matematičkom fakultetu, Univerziteta u Novom Sadu. Doktorsku disertaciju pod nazivom „Razvoj i implementacija novih senzorskih i biosenzorskih rešenja primenom koncepta Laboratorija-na-čipu“ odbranila je 2024. godine. Tokom svoje karijere, Ivana Kundačina je učestvovala u osam nacionalnih i međunarodnih istraživačkih projekata i radila kao gostujući istraživač na Tehničkom univerzitetu u Beču, Austrija, i institutu INRAe u Parizu, Francuska. Njene oblasti istraživanja uključuju mikrofluidiku, CFD simulacije, kao i razvoj senzorskih i biosenzorskih rešenja integrisanih u minijaturizovane sisteme.

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Aleksandra Pavlović je zaposlena na Institutu BioSens kao istraživač-pripravnik. Takođe, student je doktorskih akademskih studija hemije na Prirodno-matematičkom fakultetu Univerziteta u Novom Sadu, gde je završila osnovne (2019.) i master (2020.) studije hemije. Bavi se naučno-istraživačkim radom u oblasti sinteze, funkcionalizacije i karakterizacije periodično mezoporoznih organosilikatnih nanočestica za dermalnu upotrebu, kao i razvijanjem biosenzora za različite biomolekule.

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Milica Trajković je sertifikovani projektni menadžer (Project Management Professional – PMP) od strane prestižnog Instituta za projektni menadžment (Project Management Institute), sa iskustvom u projektima finansiranim od strane Evropske Komisije u oblasti digitalne poljoprivrede i razvoja IKT sektora za poljoprivredu i industriju hrane.
Kao rukovodilac Centra za Inovacije i razvoj poslovanja, ona je odgovorna za izgradnju novih i održavanje uspešnih partnerskih veza kako sa partnerima iz industrije, tako i sa akademskom zajednicom u Srbiji i Evropi. Milica rukovodi multinacionalnim projektima koji obuhvataju nekoliko različitih industrijskih sektora; rukovodi razvojem i pisanjem novih projekata (od ideje do pisanja i realizacije projektnih aktivnosti) i pruža informacije o trendovima na AgTech tržištu istraživačima Instituta. Jedan od njenih ciljeva je snažna podrška preduzetničkim poduhvatima naučnika Instituta. Uz to, Milica podstiče razvoj visokotehnoloških stratapova, MSPP sektora iz Srbije i regiona sa osnovnim ciljem da približi tehničko-tehnološku scenu regiona poljoprovredi i industriji hrane.

Maša Mimica radi kao projektni menadžer u Institutu Biosens na poslovima H2020 finansijskog menadžement ali i kao projektni menadžer podprojekata odabranih od strane Instituta. Ima bogato iskustvo iz finansijskog izveštavanja na projektnom nivou sa potfoliom od 17M€ i sa dokazanim iskustvom u planiranju, izveštavanju i analizi poslovnih potreba i drugim finansijskim aspektima Instituta. Maša kao deo Centra za inovacije i razvoj poslovanja sarađuje sa drugim odeljenjima u donošenju strateških odluka i rešavanju operativnih izazova
Paralelno s tim, Maša radi kao menadžer podprojekata finansiranih kaskadno, ranije u FP7, a sada u programu H2020. Kroz ovu vrstu poslova, stekla je veliko iskustvo u programima inovacija i akceleracije malih i srednjih preduzeća. Kroz projekte na kojima radi došlo je do pozicioniranja na tržištu i rasta više od 150 MSP, kako IT tako i poljoprivrednog sektora.
Maša ima iskustvo rada u multinacionalnom okruženju, gde je rad sa različitim stranama u raznim industrijama doprineo razvoju njenih poslovnih i međuljudskih veština.

Dr Marko Panić je naučni saradnik u oblasti tehnološko-tehničkih nauka – informacionih tehnologija na institutu BioSens. Tema doktorata mu je vezana za razvoj algoritama za ubrzanu rekonstrukciju slika iz nepotunih merenja korišćenjem retke reprezentacije signala I statističkih Markovljevih slučajnih modela Njegov pravac istraživanja obuhvata statističko modelovanje multidimenzionalnih podataka dobijenih sa različitih senzora. Trenutno radi na analizi I obradi slika dobijenih sa hiperspektralnih I multispektralnih kamera korišćenjenem naprednih metoda mašinskog učenja sa primenom u proceni kvaliteta voća I povrća. Kao član tima BioSens ucestvovao je na Sindžentinom takmičenju “Izazovu za useve” koje rezltiralo osvajanjem prvog mesta. Aktivno je uključen u mnoge projekte iz poziva Horizont 2020, među kojima su Antares, Cybele, Dragon i Flexirobots, kao i u projekte sa kompanijama poput Krivaje, MK Agri i Delta Agrar.

Teodora Knežić je zaposlena kao istraživač-pripravnik na Institutu BioSens, u Centru za biosisteme. Teodora je završila osnovne i master akademske studije molekularne biologije i trenutno pohađa doktorske akademske studije molekularne biologije na Prirodno-matematičkom fakultetu Univerziteta u Novom Sadu, pod mentorstvom dr Ivane Gađanski. Tokom svojih studija volontirala je u Laboratoriji za biohemiju i molekularnu biologiju na Prirodno-matematičkom fakultetu gde je vršila analizu genske ekspresije kukuruznog plamenca koristeći metode za izolaciju RNK, gel elektroforezu, sintezu cDNK, end-point i qPCR analizu. Takođe, na Institutu za nuklearne nauke Vinča obučena je za rad sa humanim ćelijskim linijama, izvođenje eseja vijabilnosti i protočnu citometriju. Teodora je završila i tromesečno fakultativno stručno usavršavanje na Institutu BioSens. Njen glavni fokus istraživanja je razvoj biosenzora i molekularnih tehnika za detekciju patogena, ćelijska poljoprivreda i razvoj lab-on-a-chip platformi.

Mila Đisalov je diplomirani biohemičar i master molekularne biologije. Trenutno je student doktorskih studija biohemije na Prirodno-matematičkom fakultetu u Novom Sadu i istraživač-pripravnik na Institutu BioSens. Njena glavna istraživačka interesovanja vezana su za razvoj biosenzora i molekularnih alata za detekciju patogena, ćelijska poljoprivreda i razvoj laboratorija na čipu. Mila je takođe jedan od osnivača studentske grupe The BioSense Alt. Protein Project, osnovane na Institutu BioSens.

Mila Đisalov

Dr Ivana Gađanski je viši naučni saradnik na Institutu Biosens, Univerzitet u Novom Sadu, Srbija. Diplomirala je na Biološkom fakultetu Univerziteta u Beogradu kao prva u klasi (2003). Doktorirala je iz neuronauka (ocena summa cum laude – usmena odbrana) na Georg-August Univerzitetu i Institutu za biofizičku hemiju Maks Plank, Getingen, Nemačka (2007) i radila na posledoktorskim studijama na Univerzitetu Ludvig-Maksimilijian, Minhen, Nemačka. Ivana se zatim posvetila oblasti bioinženjerstva i provela godinu dana kao Fulbrajt stipendista – gostujući istraživač na Univerzitetu Kolumbija, Njujork, SAD u Laboratoriji za matične ćelije i tkivno inženjerstvo (rukovodilac: prof. Gordana Vunjak-Novaković). U BioSensu radi na bioinženjerstvu u oblasti ćelijske poljoprivrede - razvija rešenja za kultivisano meso. Takođe radi na razvoju biosenzora za monitoring u oblasti poljoprivrede, biomedicine i zaštite životne sredine. Ivana je stipendista Instituta za dobru hranu i koordinator Horizont2020 projekata DRAGON GA 810755 i IPANEMA GA 872662.

Ovaj projekat je finansiran od strane Evropske Unije, iz programa za Istraživanje i Inovacije-  Horizont 2020, pod sporazumom o grantu broj 952259.      

Horizont 2020

Srce-na-čipu baziran na tehnologiji indukovanih pluripotentnih matičnih ćelija za primenu u lečenju i terapiji pacijenata.

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Portabilni maseni spektrometar sa kvadropolnim analizatorom za istraživanje efekata uzimanja hrane kod potrošača radi personalizovane nutritivnosti

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Zaštita kože od UV zračenja bazirana na nanomaterijalima

Selektivna terapija kancera bazirana na sporom otpuštanju lekova iz silikatnih nanomaterijala

Primene u medicini

Biomolekuli su molekuli su koji omogućavaju funkcionisanje živih organizama, uključujući DNK, RNK, proteine, peptide i konstelaciju malih molekula koji se sintetišu u ćelijama. Biomolekularno inženjerstvo (BMI) obuhvata ispitivanje i inženjerstvo svih ovih živih sistema. BMI istraživanja koriste tehnike i metode iz sintetičke biologije, sistemske biologije, biomedicinskih istraživanja i biotehnologije, biohemije i biofizike bioloških sistema i ćelijske biologije za kvantifikovanje i manipulisanje strukturom i funkcijom molekula i makromolekularnih sklopova za potencijalne primene u sledećim oblastima:

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· Biotehnologija: Biosenzorski i bioanalitički uređaji, tehnologije ćelijskih kultura sa omogućenom mikrofluidikom (npr. organi na čipu), razvoj i primena novih molekularnih alata detekcije patogena (primenljivo za procenu bezbednosti hrane)

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· Osnovni procesi živih sistema: interakcije patogena i domaćina, ćelijska i unutarćelijska organizacija

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· Bolesti ljudi i životinja: dizajn i inženjerstvo dijagnostičkih metodologija, ćelijsko i tkivno inženjerstvo
Pored toga, BMI istraživanja uključuju veoma interdisciplinarne aktivnosti, kao što su nauka o materijalima i nano- i mikroelektronika, kao i računarstvo i primenjena matematika. U tom smislu, BMI je vrlo dobar primer bliske multidisciplinarne saradnje između Centra za biosisteme i druga dva centra u okviru BioSens Instituta - Centra za senzorske tehnologije i Centra za informacione tehnologije.

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Projekti:

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H2020 MSCA-RISE IPANEMA GA 872662 - Integration of PAper-based Nucleic acid testing mEthods into Microfluidic devices for improved biosensing Applications

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<img class="alignnone wp-image-1421 size-full" src="https://api.biosens.rs/wp-content/uploads/2021/06/bs6.jpg" alt="" width="1100" height="624" />

Biomolekularno inženjerstvo

Biosenzori su analitički uređaji koji služe za detekciju biološkog materijala kao što su biomolekuli, biološke strukture ili mikroorganizmi (bakterije, virusi, alge, spore). Široku primenu biosenzori nalaze u kontroli bezbednosti hrane, monitoringu životne sredine, kao i u ranom otkrivanju infektivnih bolesti u biomedicini.

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Naša istraživanja su usmerena na razvoj novih biosenzorskih transdjusera, biofunkcionalizaciju senzora sa bioreceptorima, i integraciju senzora u mikrofluidične sisteme. Razvijeni senzori se koriste za detekciju bakterija u hrani i vodi, za detekciju cijano toksina nastalih tokom cvetanja algi, kao i za brzu detekciju fekalnih bakterija i drugih mikrobioloških patogena u vodi.

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Bavimo se i razvojem novih nanomaterijala za funkcionalizaciju biosenzorskih elektroda i fabrikaciju novih elektrohemijskih biosenzora koristeći različite tehnologije fabrikacije. Deo istraživanja je usmeren na nove materijale koji će omogućiti selektivno i efikasno vezivanje analita, kao i na projektovanje biosenzora u cilju poboljšanja njihove selektivnosti, osetljivosti i limita detekcije. Bavimo se i novim metodama modifikacije grafena, novim metodama za njegovu sintezu i integraciju u konvencionalne industrijske procese.

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Posebna pažnja je posvećena biosenzorima na bazi enzima, antitela i nukleinskih kiselina (DNK, RNK). Ova istraživanja se izvode u bliskoj saradnji sa Centrom za biosisteme u kojem istraživači rade na metodama biomolekularnog inženjerstva i molekularne dijagnostike što uključuje i najsavremenije izotermalne metode za umnožavanje nukleinskih kiselina kao što su LAMP (Loop Mediated Isothermal Amplification) i RPA (Recombinase Polymerase Amplification) koje se mogu dobro kombinovati sa biosenzorima razvijenim u okviru Centra za senzorske tehnologije.

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Takođe, Institut BioSens radi na novim vrstama biosenzora za monitoring hranljivih materija i produkata metabolizma ćelija u procesu proizvodnje kultivisanog mesa, što je još jedan primer dobre multidisciplinarne saradnje sa Centrom za biosisteme i istraživačima koji rade u okviru oblasti ćelijske poljoprivrede.

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<img class="alignnone wp-image-1508 " src="https://api.biosens.rs/wp-content/uploads/2021/06/58.png" alt="" width="701" height="417" />

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Zajednički projekti sa Centrom za biosisteme:

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H2020 MSCA-RISE IPANEMA GA 872662 - Integration of PAper-based Nucleic acid testing mEthods into Microfluidic devices for improved biosensing Applications

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REALSENSE1 - Monitoring of cell culture parameters using sensors for biomass and nutrients/metabolites in media: Lab-on-a-Chip (LOC) approach, 2019-2021; Good Food Institute Inaugural Competitive Grant Program.

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REALSENSE2 – From lab-on-a-chip to custom bioreactor: scale up modeling study, 2020-2022 Good Food Institute Competitive Grant Program

Biosenzori

Mikrofluidika je oblast koja se bavi manipulacijom i kontrolom malih količina fluida u mikro- i nano-kanalima i kao takva mikrofludika je napravila pravu malu revoluciju u mikrobiološkim, medincinskim i hemijskim analizama.

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Naša istraživanja su fokusirana na analizu i projektovanje različitih mikrofludičinih komponenta, razvoj novih materijala za mikrofluidične čipove i integraciju mikrofluidike sa različitim sistemima za detekciju i elektronikom. U tu svrhu koristimo različite tehnologije fabrikacije, kao što su Polidimetilsiloksan (PDMS), niskotemperaturna zajedno pečena keramika (LTCC), 3D, inkdžet i bio-štampa, ksirografija, kao i hibridne tehnologije.
Kako korišćenje samo jedne tehnologije fabrikacije ne može da ispuni sve zahteve savremenih mikrofluidičnih sistema, koristimo hibridni pristup - kombinujemo različite tehnologije sa različitim materijalima da bismo dobili mikrofluidične čipove sa visokom rezolucijom, malim dimenzijama i visokim protocima. Na primer, hibridni pristup se koristi za razvoj višeslojnih čipova za filtraciju, mešača fluida za visoke protoke, kao i separatora za polen.

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Takođe, integrišemo mikrofluidne čipove sa reagentima za analizu na čipu sa različitim tipovima senzora u cilju razvoja labratorije na čipu za detekciju parametara fluida, koji nalaze primenu u kontroli mešanja fluida, biomedicine, monitoringu ekosistema i analizi tečne hrane.
Osim toga, radimo na razvoju mikrofluidičnog reaktora, koji integriše sistem za ćelijsku kulturu, različite senzore za detekciju koncentracije hranljivih materija i merenje metaboličkih otpadnih proizvoda, optičku detekciju i elektroniku u jedan jedinstveni sistem na čipu.

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Prateći ovaj koncept, razvijamo i mikrofluidičnu platformu koja ima mogućnost da reprodukuje dinamiku i heterogenost zemljišta na taj način razvijajući sistem za monitoring interakcije između biljke i mikrobioma.

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<img class="alignnone wp-image-1529 size-full" src="https://api.biosens.rs/wp-content/uploads/2021/06/70.jpg" alt="" width="763" height="323" />

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PROJEKTI:

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CISTEM - Heart On chip based on induced pluripotent Stem cell Technology for personalized Medicine, H2020-MSCA-RISE-2017, GA No. 778354

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REALSENSE1 - Monitoring of cell culture parameters using sensors for biomass and nutrients/metabolites in media: Lab-on-a-Chip (LOC) approach, 2019-2021; Good Food Institute Inaugural Competitive Grant Program.

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IPANEMA - Integration of PAper-based Nucleic acid testing mEthods into Microfluidic devices for improved biosensing Applications, H2020-MSCA-RISE-2019, 2020-2024. GA No. 872662,

Mikrofluidika

Zbog malog prečnika (oko 100 nm) i veoma porozne prirode, mezoporozne silikatne nanočestice (MSN) imaju veliku specifičnu površinu (oko 1000 m2 / g) koja se može koristiti za različite funkcionalizacije, punjenje/adsorpciju različitih molekula i njihovo uklanjanje, ili kao platforma za signalne molekule za detekciju različitih analita.

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Mezoporozni organosilikatni nanomaterijal (Periodični mezoporozni organosilikat (PMO)) sadrži veliki procenat organskih grupa, što omogućuje da ispoljavaju jedinstvene karakteristike za različite primene.

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Naše istraživanje se provodi u cilju dizajniranja novih serija MSN i PMO nanomaterijala, kao i njihovih jezgro / ljuska analoga.

Površina ovih nanomaterijala se modifikuje različitim molekulima kako bi specifično stupila u interakciju sa željenim tkivima, zagađivačima ili analitima, radi njihove efikasne primene u praćenju i zaštiti zdravlja, hrane i životne sredine.

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Jedan od ciljeva istraživanja je razvoj pametnih nanomaterijala sa stimulans-responzivnim oslobađanjem molekula iz MSN / PMO materijala, sa primenom u dijagnostici, snimanju i terapiji tkiva raka.
Kompozitni materijali polimer-MSN se takođe razvijaju u cilju primene kao antimikrobnih pametnih ambalaža za hranu i medicinskih implanata.

Konačno, nove PMO nanočestice se konstruišu radi efikasnog blokiranja UVA i UVB zračenja i primene u bezbednijoj generaciji krema za sunčanje.

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<img class="alignnone wp-image-1626 size-full" src="https://api.biosens.rs/wp-content/uploads/2021/06/slika-1.png" alt="" width="837" height="466" />

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Projekti:

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PRECAST: Prediction of Cancer Treatment Effectiveness with Stimuli-responsive Nanomaterials, Science Fund of the Republic of Serbia

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<a href="https://cordis.europa.eu/project/id/952259">NANOFACTS: Networking Activities for Nanotechnology-Facilitated Cancer Theranostics H2020-WIDESPREAD-2020-5</a>

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Novel Active Components for Health- and Enviroment-friendly UV-Blocking Based on Enriched Organosilica Nanomaterials, Project ID: 5566, The Innovation Fund of the Republic of Serbia

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III 44006 Razvoj novih informaciono-komunikacionih tehnologija, korišćenjem naprednih matematičkih metoda, sa primenama u medicini, telekomunikacijama, energetici, zaštiti nacionalne baštine i obrazovanju, Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije.

NANOFACTS – Networking Activities for Nanotechnology-Facilitated Cancer Theranostics

Themes:

People:

Centers:

CST

CIRP