MicoLabAptaSens- Microfluidic Lab-on-a-Chip platform for fast detection of pathogenic bacteria using novel electrochemical aptamer-based biosensors

Acronym: MicoLabAptaSens

Implementation period: 01/01/2022 - 31/12/2024

Type of Project: National

Reference: 7750276

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Project aim: MicroLabAptaSens intends to make innovations in biosensor development for multiple pathogens detection for easy and fast detection in food safety, environmental monitoring, and healthcare.

 

About the project: Foodborne bacterial diseases are a growing public health concern at the global level and one of the most important requirements in food safety is the development of accurate and early diagnostic tools for foodborne diseases. Project MicroLabAptaSens exploits complementary knowledge and expertise of the excellent scientists in order to: 1) Perform cutting edge research in the multidisciplinary field of sensors, microfluidics, nanomaterials, biotechnology and food safety with a main objective to 2) Develop innovative low-cost sensing devices for detection of the 3 most foodborne bacteria (Listeria monocytogenes, Salmonella enteritidis and Campylobacter jejuni) applicable for the in-situ point-of-need (PON) use and to 3) Fabricate and validate microfluidic (MF) Lab-on-a-Chip (LoC) tests with integrated sensor and on-chip reagent storages, finally aiming to 4) Pursue real-life applications in agrifood and biotech sectors. Novelty relies on a novel class of nanomaterial-functionalized aptamer-based biosensors suitable for integration into unique low-cost LoC MF tests. Application of advanced micro- and nano-technologies will allow integration with reagents for multiple pathogen analysis into user-friendly fast tests which will not require costly lab equipment, trained personnel, and special conditions. Such tests fit all the ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and robust, Equipment-free and Deliverable to end-users) criteria recommended by the World Health Organization (WHO). The electronic readout module and smartphone application will be developed for data processing and visualization. The final goal is a cost-efficient sensing device that can satisfy market-needs and MF tests for applications in healthcare, environment monitoring and food safety sectors and can be easily scaled-up to the mass production or adapted for other specific applications such as viral or bacterial airborne pathogens detection.

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